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Some Tips On Power Chords
A very interesting use for the #5 power chord is that it may act as a replacement for a major chord. In fact, if you look at the root (duplicated at the octave) of the #5 power chord as the third of a major chord, then the augmented 5th can be seen as the root of that major chord.
When any chord note other than the root is in the bass of a chord, then that chord is called an inversion. We may then say that our #5 power chord acts as an inversion of a major chord.
If you listen to AC/DC's "Back in Black" main riff, which uses the chord sequence E-D-A, you'd hear the bass playing roots on the first two chords, but the third on the last chord. We can then recreate that distinctive sound by replacing the A chord with a C#(#5) power chord: